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Afflictions, Poisons & Diseases

Diseases

Abyssal Plague Disease 9

Sources of this hazard night hags

The target can’t recover from the drained condition from Abyssal plague until the disease is cured. Stage 1 drained 1 (1 day); Stage 2 drained increases by 2 (1 day).

Critical Success The target is unaffected.

Success The target takes 2 evil damage per spell level, and takes a –2 status penalty to saves against Abyssal plague for 1 day or until the target contracts it, whichever comes first.

Failure The target is afflicted with Abyssal plague at stage 1.

Critical Failure The target is afflicted with Abyssal plague at stage 2.

Avernal Fever Disease ?

Sources of this hazard

Saving Throw DC 23 Fortitude; Stage 1 carrier with no ill effect (1 day); Stage 2 enfeebled 1 (1 day); Stage 3 enfeebled 2 (1 day)

Cacodaemonia Disease ?

Sources of this hazard

The cacodaemon can telepathically communicate with the afflicted creature at any distance on the same plane

Saving Throw DC 17 Fortitude; Stage 1 carrier (1 day); Stage 2 stupefied 1 (1 day); Stage 3 stupefied 2 (1 day)

Daemonic Pestilence Disease ?

Sources of this hazard

The leukodaemon can telepathically communicate with the afflicted creature at any distance on the same plane

Saving Throw DC 28 Fortitude; Stage 1 carrier (1 day); Stage 2 drained 1 (1 day); Stage 3 drained 2 (1 day); Stage 4 drained 2 (1 day); Stage 5 drained 3 (1 week); Stage 6 dead

Filth Fever Disease ?

Sources of this hazard giant rats, otyughs

The sickened and unconscious conditions from filth fever don’t improve on their own until the disease is cured.; Saving Throw DC 14 Fortitude; Stage 1 carrier with no ill effect (1d4 hours), Stage 2 sickened 1 (1 day), Stage 3 sickened 1 and slowed 1 (1 day), Stage 4 unconscious (1 day), Stage 5 dead

Ghoul Fever Disease 3

Sources of this hazard ghouls, ghasts

Stage 1 carrier with no ill effects (1 day); Stage 2 3d8 negative damage and the creature regains half as many Hit Points from all healing (1 day); Stage 3 as stage 2 (1 day); Stage 4 3d8 negative damage and the creature gains no benefit from healing (1 day); Stage 5 as stage 4 (1 day); Stage 6 the creature dies and rises as a ghoul at the next midnight

Critical Success The target is unaffected.

Success The target is afflicted with ghoul fever at stage 1.

Failure The target is afflicted with ghoul fever at stage 2.

Critical Failure The target is afflicted with ghoul fever at stage 3.

Goblin Pox Disease 1

Sources of this hazard goblins, goblin dogs

Goblins and goblin dogs are immune. Stage 1 sickened 1 (1 round); Stage 2 sickened 1 and slowed 1 (1 round); Stage 3sickened 1 and the creature can’t reduce its sickened value below 1 (1 day)

Critical Success The target is unaffected.

Success The target is sickened 1.

Failure The target is afflicted with goblin pox at stage 1.

Critical Failure The target is afflicted with goblin pox at stage 2.

Spore Blight Disease ?

Sources of this hazard terotricus

Plants and fungi are immune. Saving Throw Fortitude DC 40; Stage 1 enfeebled 2 (1 day); Stage 2 enfeebled 4 and slowed 1 (1 day); Stage 3 controlled by the terotricus (as dominate; 5d8 days); Stage 4 dead.

Wasp Larva Disease ?

Sources of this hazard giant wasps

Saving Throw Fortitude DC 21; Stage 1 carrier with no ill effect (1d6 days); Stage 2 drained 1 (1d3 days); Stage 3 5d6 damage, larva emerges (disease ends)

Wretched Weeps Disease ?

Sources of this hazard ofalth

Saving Throw DC 26 Fortitude; Stage 1 carrier with no ill effect (1 day); Stage 2 2d8 persistent bleed damage every hour and enfeebled 1 (1 day); Stage 3 2d8 persistent bleed damage every hour and enfeebled 2 (1 day)

Poisons

Arsenic Item 1

Alchemical Consumable Ingested Poison

Price 3 gp
Usage held in 1 hand; Bulk L


This toxin is a compound of arsenic and other substances. You can’t reduce your sickened condition while affected.


Saving Throw DC 18 FortitudeOnset 10 minutes; Maximum Duration 5 minutes; Stage 1 1d4 poison damage and sickened 1 (1 minute); Stage 2 1d6 poison damage and sickened 2 (1 minute); Stage 3 2d6 poison damage and sickened 3 (1 minute)
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Belladonna Item 2

Alchemical Consumable Ingested Poison

Price 5 gp
Usage held in 1 hand; Bulk L


Sometimes called “deadly nightshade,” belladonna is a widely available toxin produced from a plant similar to a tomato.


Saving Throw DC 19 FortitudeOnset 10 minutes; Maximum Duration 30 minutes; Stage 1 dazzled (10 minutes); Stage 2 1d6 poison damage and sickened 1 (10 minutes); Stage 3 1d6 poison damage, confused, and sickened 1 (1 minute)
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Black Adder Venom Item 2

Alchemical Consumable Injury Poison

Price 6 gp
Usage held in 2 hands; Bulk L


Adder venom is a simple but effective way to enhance a weapon.


Saving Throw DC 18 FortitudeMaximum Duration 3 rounds; Stage 1 1d8 poison damage (1 round); Stage 2 1d10 poison damage (1 round); Stage 3 2d6 poison damage (1 round)
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Black Lotus Extract Item 19

Alchemical Consumable Contact Poison Virulent

Price 6,500 gp
Usage held in 1 hand; Bulk L


Black lotus extract causes severe internal bleeding.


Saving Throw DC 42 FortitudeOnset 1 minute; Maximum Duration 6 rounds; Stage 1 15d6 poison damage and drained 1 (1 round); Stage 2 17d6 poison damage and drained 1 (1 round); Stage 3 20d6 poison damage and drained 2 (1 round)
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Black Smear Poison Item 2

Uncommon Alchemical Consumable Injury Poison

Source Bestiary
Price 5 gp
Usage held, 2 hands; Bulk L


Many calignis use a debilitating poison crafted from subterranean fungi.


Saving Throw DC 16 FortitudeMaximum Duration 6 rounds; Stage 1 1d6 poison and enfeebled 1 (1 round); Stage 2 As stage 1; Stage 3 1d6 poison, and enfeebled 2 (1 round)
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Blightburn Resin Item 11

Alchemical Consumable Contact Poison

Price 225 gp
Usage held in 2 hands; Bulk L


This tacky, hardened sap is harvested from trees infected by fungal blights and exposed to open flames. 


Saving Throw DC 31 FortitudeOnset 1 minute; Maximum Duration 6 rounds; Stage 1 8d6 poison damage (1 round); Stage 2 10d6 poison damage (1 round); Stage 3 15d6 poison damage (1 round)
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Blue Dragonfly Poison Item 3

Uncommon Alchemical Consumable Ingested Poison

Source Bestiary
Price 7 gp
Usage held in 1 hand; Bulk L


Boggards brew a potent toxin made from blue dragonflies. Swampseers consume this mixture to awaken their divine powers, but the poison inspires crippling hallucinations in most other creatures.


Saving Throw DC 17 FortitudeOnset  10 minutes; Maximum Duration 30 minutes; Stage 1 dazzled (10 minutes); Stage 2 dazzled and frightened 1 (10 minutes); Stage 3 frightened 1 and confused 1 (1 minute)
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Brimstone Fumes Item 16

Alchemical Consumable Evil Inhaled Poison

Price 1,500 gp
Usage held in 1 hand; Bulk L


Fumes from the forges of Hell drain health and strength alike. 


Saving Throw DC 36 FortitudeOnset 1 round; Maximum Duration 6 rounds; Stage 1 7d6 poison damage and enfeebled 1 (1 round); Stage 2 8d6 poison damage and enfeebled 2 (1 round); Stage 3 10d6 poison damage and enfeebled 3 (1 round)
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Cytillesh Oil Item 3

Alchemical Consumable Injury Poison

Price 10 gp
Usage held in 2 hands; Bulk L


This thick substance is distilled from the mind-robbing cytillesh fungus, though it lacks memory-altering capabilities. 


Saving Throw DC 19 FortitudeMaximum Duration 4 rounds; Stage 1 1d10 poison damage (1 round); Stage 2 1d12 poison damage (1 round); Stage 32d10 poison damage (1 round)
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Deathcap Powder Item 13

Alchemical Consumable Ingested Poison

Price 450 gp
Usage held in 2 hands; Bulk L


The toxic deathcap mushroom can be dried, ground, and treated to form a flavorless powder with accelerated effects.


Saving Throw DC 33 FortitudeOnset 10 minutes; Maximum Duration 6 minutes; Stage 1 13d6 poison damage (1 minute); Stage 2 17d6 poison damage and sickened 2 (1 minute); Stage 3 20d6 poison damage and sickened 3 (1 minute)
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Dragon Bile Item 15

Alchemical Consumable Contact Poison

Price 925 gp
Usage held in 2 hands; Bulk L


A mix of digestive juices and green dragon poison glands nauseates the victim as its flesh is digested from within.


Saving Throw DC 37 FortitudeOnset 1 minute; Maximum Duration 6 rounds; Stage 1 6d6 poison damage and sickened 2 (1 round); Stage 2 7d6 poison damage and sickened 3 (1 round); Stage 3 9d6 poison damage and sickened 4 (1 round)
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Drider Venom

Saving Throw DC 23 Fortitude; Maximum Duration 6 rounds; Stage 1 1d8 poison damage and enfeebled 1 (1 round)

Ether Spider Venom (poison); Saving Throw DC 22 Fortitude; Maximum Duration 6 rounds; Stage 1 1d6 poison damage and clumsy 1 (1 round); Stage 2 2d6 poison damage, clumsy 2 and slowed 1 (1 round); Stage 3 3d6 poison damage, clumsy 3 and slowed 2 (1 round)

Giant Octopus Venom Item ?

Saving Throw DC 26 Fortitude; Maximum Duration 6 rounds; Stage 1 2d6 poison damage and flat-footed (1 round); Stage 2 2d6 poison damage, clumsy 1, and flat-footed (1 round); Stage 3 2d6 poison damage, clumsy 2, and flat-footed (1 round)

Giant Centipede Venom Item 1

Alchemical Consumable Injury Poison

Price 4 gp
Usage held in 2 hands; Bulk L


Giant centipede venom causes severe muscle stiffness.


Saving Throw DC 17 FortitudeMaximum Duration 6 rounds; Stage 1 1d6 poison damage (1 round); Stage 2 1d8 poison damage and flat-footed (1 round); Stage 3 1d12 poison damage, clumsy 1, and flat-footed (1 round)
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Giant Scorpion Venom Item 6

Alchemical Consumable Injury Poison

Price 40 gp
Usage held in 2 hands; Bulk L


Scorpion venom is excruciating and its effects are somewhat debilitating.


Saving Throw DC 22 FortitudeMaximum Duration 6 rounds; Stage 1 1d10 poison damage and enfeebled 1 (1 round); Stage 2 2d10 poison damage and enfeebled 1 (1 round); Stage 3 2d10 poison damage and enfeebled 2 (1 round)
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Giant Wasp Venom Item 7

Alchemical Consumable Injury Poison

Price 55 gp
Usage held in 2 hands; Bulk L


Giant wasp venom interferes with a victim’s movement. 


Saving Throw DC 25 FortitudeMaximum Duration 6 rounds; Stage 1 2d6 poison damage and clumsy 1 (1 round); Stage 2 3d6 poison damage and clumsy 2 (1 round); Stage 3 4d6 poison and clumsy 2 (1 round)
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Graveroot Item 3

Alchemical Consumable Injury Poison

Price 10 gp
Usage held in 2 hands; Bulk L


The opaque white sap from the graveroot shrub clouds the mind.


Saving Throw DC 19 FortitudeMaximum Duration 4 rounds; Stage 1 1d10 poison damage (1 round); Stage 2 1d12 poison damage and stupefied 1 (1 round); Stage 3 2d6 poison damage and stupefied 2 (1 round)
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Hemlock Item 17

Alchemical Consumable Ingested Poison

Price 2,250 gp
Usage held in 1 hand; Bulk L


Concentrated hemlock is a particularly deadly toxin that halts muscle action—including that of the victim’s heart.


Saving Throw DC 40 FortitudeOnset 30 minutes; Maximum Duration 60 minutes; Stage 1 17d6 poison damage and enfeebled 2 (10 minutes); Stage 221d6 poison damage and enfeebled 3 (10 minutes); Stage 3 26d6 poison damage and enfeebled 4 (10 minutes) 
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Hunting Spider Venom Item 5

Alchemical Consumable Injury Poison

Price 25 gp
Usage held in 2 hands; Bulk L


This venom erodes its target’s defenses, aiding the spider in securing prey.


Saving Throw DC 21 FortitudeMaximum Duration 6 rounds; Stage 1 1d10 poison damage and flat-footed (1 round); Stage 2 1d12 poison damage, clumsy 1, and flat-footed (1 round); Stage 3 2d6 poison damage, clumsy 2, and flat-footed (1 round)
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King’s Sleep Item 18

Alchemical Consumable Ingested Poison Virulent

Price 4,000 gp
Usage held in 1 hand; Bulk L


King’s sleep is an insidious long-term poison that can seem like a disease or even death from natural causes on a venerable target. The drained condition from king’s sleep is cumulative with each failed save and can’t be removed while the poison lasts.


Saving Throw DC 41 FortitudeOnset 1 day; Stage 1 drained 1 (1 day); Stage 2 drained 1 (1 day); Stage 3 drained 2 (1 day)
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Kraken Ink Item ?

Krakens are immune to this poison.; Saving Throw DC 39 Fortitude; Maximum Duration 10 rounds; Stage 1 3d6 poison damage and sickened 1 (1 round); Stage 2 4d6 poison damage and sickened 2 (1 round).

Lethargy Poison Item 2

Uncommon Alchemical Consumable Incapacitation Injury Poison Sleep

Price 7 gp
Usage held in 2 hands; Bulk L


Lethargy poison is commonly used in hit-and-run tactics by drow and others who want their victims alive; the ambusher retreats until the poison sets in and the victim falls unconscious. Further exposure to lethargy poison does not require the target to attempt additional saving throws; only failing an saving throw against an ongoing exposure can progress its stage.


Saving Throw DC 18 FortitudeMaximum Duration 4 hours; Stage 1 slowed 1 (1 round); Stage 2 slowed 1 (1 minute); Stage 3 unconscious with no Perception check to wake up (1 round) Stage 4 unconscious with no Perception check to wake up (1d4 hours). 
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Lich Dust Item 9

Alchemical Consumable Ingested Poison

Price 110 gp
Usage held in 1 hand; Bulk L


Dust salvaged from the remains of a destroyed lich has paralytic properties that make it a valuable poison.


Saving Throw DC 28 FortitudeOnset 10 minutes; Maximum Duration 6 minutes; Stage 1 fatigued (1 minute); Stage 2 5d6 poison damage and fatigued (1 minute); Stage 3 5d6 poison damage, fatigued, and paralyzed (1 minute)
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Malyass Root Paste Item 7

Alchemical Consumable Contact Poison

Price 55 gp
Usage held in 2 hands; Bulk L


Malyass root paste sees use to impede opponents in athletic competitions, in addition to espionage and tracking.


Saving Throw DC 26 FortitudeOnset 1 minute; Maximum Duration 6 minutes; Stage 1 clumsy 1 and –10-foot status penalty to all Speeds (1 minute); Stage 2 clumsy 2 and –20-foot status penalty to all Speeds (1 minute); Stage 3 clumsy 3, flat-footed, and –30-foot status penalty to all Speeds
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Medusa Serpent Venom

Saving Throw DC 25 Fortitude; Maximum Duration 6 rounds; Stage 1 1d6 poison damage and enfeebled 1 (1 round); Stage 2 2d6 poison damage and enfeebled 2 (1 round)

Mindfog Mist Item 15

Alchemical Consumable Inhaled Poison

Price 1,000 gp
Usage held in 1 hand; Bulk L


Mindfog mist can be used to undermine spellcasters, as its effect on a victim’s mental faculties are swift and powerful.


Saving Throw DC 35 FortitudeOnset 1 round; Maximum Duration 6 rounds; Stage 1 stupefied 2 (1 round); Stage 2 confused and stupefied 3 (1 round); Stage 3 confused and stupefied 4 (1 round)
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Nettleweed Residue Item 8

Alchemical Consumable Contact Poison

Price 75 gp
Usage held in 2 hands; Bulk L


Concentrated sap of stinging weeds makes an effective toxin.


Saving Throw DC 27 FortitudeOnset 1 minute; Maximum Duration 6 minutes; Stage 1 8d6 poison damage (1 minute); Stage 2 10d6 poison damage (1 minute); Stage 3 13d6 poison damage (1 minute)
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Nightmare Vapor Item 16

Alchemical Consumable Inhaled Poison

Price 1,400 gp
Usage held in 1 hand; Bulk L


Purportedly sourced from any number of outlandish locales, nightmare vapor is most often created by boiling the sweat collected from humanoids caught in the throes of terrible nightmares.


Saving Throw DC 36 FortitudeOnset 1 round; Maximum Duration 6 rounds; Stage 1 confused (1 round); Stage 2 confused and flat-footed (1 round); Stage 3 confused, flat-footed, and stupefied 2 (1 round)
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Purple Worm Venom Item 13

Alchemical Consumable Injury Poison

Price 500 gp
Usage held in 2 hands; Bulk L


Venom from enormous purple worms leaves a victim weakened.


Saving Throw DC 32 FortitudeMaximum Duration 6 rounds; Stage 1 5d6 poison damage and enfeebled 2 (1 round); Stage 2 6d6 poison damage and enfeebled 2 (1 round); Stage 3 8d6 poison and enfeebled 2 (1 round)
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Reefclaw Venom

Saving Throw DC 17 Fortitude; Maximum Duration 4 rounds; Stage 1 1d6 poison damage and enfeebled 1 (1 round), Stage 2 1d6 poison damage and enfeebled 2 (1 round).

Shadow Essence Item 10

Alchemical Consumable Injury Negative Poison

Price 160 gp
Usage held in 2 hands; Bulk L


Distilled from the Plane of Shadow, this oily substance imposes tenebrous effects. The enfeebled condition from shadow essence lasts for 24 hours.


Saving Throw DC 29 FortitudeMaximum Duration 6 rounds; Stage 1 3d6 negative damage and 2d6 poison damage (1 round); Stage 2 3d6 negative damage, 2d6 poison damage, and enfeebled 1 (1 round); Stage 3 3d6 negative damage, 2d6 poison damage, and enfeebled 2 (1 round)
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Shuln Saliva (incapacitation, poison); Saving Throw DC 32 Fortitude; Maximum; Duration 6 rounds; Stage 1 2d6 poison damage and slowed 1 (1 round); Stage 2 3d6 poison damage, and slowed 1 (1 round); Stage 3 4d6 poison damage and paralyzed for 2d6 hours. Shuln saliva overcomes the inexorable ability.

Slumber Wine Item 12

Alchemical Consumable Ingested Poison Sleep

Price 325 gp
Usage held in 1 hand; Bulk L


Slumber wine sees its greatest use in games of intrigue, where an absence can be more devastating than injury. Characters unconscious from slumber wine can’t wake up by any means while the poison lasts, don’t need to eat or drink while unconscious in this way, and appear to be recently dead unless an examiner succeeds at a DC 40 Medicine check.


Saving Throw DC 32 FortitudeOnset 1 hour; Maximum Duration 7 days; Stage 1 unconscious (1 day); Stage 2 unconscious (2 days); Stage 3 unconscious (3 days).
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Spider Root Item 9

Alchemical Consumable Contact Poison

Price 110 gp
Usage held in 2 hands; Bulk L


A paste made by mashing the fine, threadlike roots of a certain creeper vine, spider root renders a victim clumsy and maladroit.


Saving Throw DC 28 FortitudeOnset 1 minute; Maximum Duration 6 minutes; Stage 1 8d6 poison damage and clumsy 1 (1 minute); Stage 2 9d6 poison damage and clumsy 2 (1 minute); Stage 3 10d6 poison damage and clumsy 3 (1 minute)
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Spider Venom Item 1

Maximum Duration 4 rounds. Stage 1 1d4 poison damage and enfeebled 1 (1 round); Stage 2 1d4 poison damage and enfeebled 2 (1 round).

Critical Success The target is unaffected.

Success The target takes 1d4 poison damage.

Failure The target is afflicted with spider venom at stage 1.

Critical Failure The target is afflicted with spider venom at stage 2.

Tears of Death Item 20

Alchemical Consumable Contact Poison Virulent

Price 12,000 gp
Usage held in 2 hands; Bulk L


Tears of death are among the most powerful of alchemical poisons, distilled from extracts of five other deadly poisons in just the right ratios.


Saving Throw DC 46 FortitudeOnset 1 minute; Maximum Duration 10 minutes; Stage 1 18d6 poison damage and paralyzed (1 round); Stage 2 25d6 poison damage and paralyzed (1 minute); Stage 3 30d6 poison damage and paralyzed (1 minute)
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Wolfsbane Item 10

Alchemical Consumable Ingested Poison

Price 155 gp
Usage held in 1 hand; Bulk L


Wolfsbane appears in folklore for its link to werecreatures. If you are afflicted with lycanthropy and survive Stage 3 of wolfsbane, you’re immediately cured of the lycanthropy.


Saving Throw DC 30 FortitudeOnset 10 minutes; Maximum Duration 6 minutes; Stage 1 12d6 poison damage (1 minute); Stage 2 16d6 poison damage (1 minute); Stage 3 20d6 poison damage (1 minute)
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Wyvern Poison Item 8

Alchemical Consumable Injury Poison

Price 80 gp
Usage held in 2 hands; Bulk L


Properly harvested and preserved, the poison from a wyvern’s sting is effective and direct.


Saving Throw DC 26 FortitudeMaximum Duration 6 rounds; Stage 1 5d6 poison damage (1 round); Stage 2 6d6 poison damage (1 round); Stage 3 8d6 poison damage (1 round)
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Section 15: Copyright Notice
Pathfinder Core Rulebook (Second Edition) © 2019, Paizo Inc.; Designers: Logan Bonner, Jason Bulmahn, Stephen Radney-MacFarland, and Mark Seifter.